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1. What Sustanon 250 is and what it is used for
Sustanon 250 is a clear pale yellow solution for injection containing the active ingredient testosterone in 4 (250 mg/ml) separate forms. The active substances of Sustanon 250 (see section 6 “What Sustanon 250 contains”) are turned into by your body. Testosterone is a natural male hormone known as an androgen.
In men, testosterone is produced by the testicles. It is necessary for the normal growth, development and function of the male sex organs and for secondary male sex characteristics. It is necessary for the growth of body hair, the development of bones and muscles, and it stimulates the production of red blood cells. It also makes men’s voices deepen.
Sustanon 250 is used in adult men for testosterone replacement to treat various health problems caused by a lack of testosterone (male hypogonadism). This should be confirmed by two separate blood testosterone measurements and also include clinical symptoms such as impotence, infertility, low sex drive, tiredness, depressive moods and bone loss caused by low hormone levels.
Sustanon 250 may also be used as supportive therapy for female-to-male transsexuals.
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2. What you need to know before Sustanon 250 is administered
Do not take Sustanon 250:
If you are pregnant or think you may be pregnant (see “Pregnancy, breast-feeding and fertility”).
If you have or have had a tumour of your prostate or breast, or are suspected to have one of these tumours.
In children under the age of 3 years.
If you are allergic to testosterone or to any of the other ingredients of this medicine (listed in section 6)
If you are allergic to peanuts or soya (see Section 2 “Important information about some of the ingredients of Sustanon 250”).
Warnings and precautions
If you notice any signs of masculinisation (for instance lowering of the voice or increase in body or facial hair), consult your doctor immediately.
Treatment with male hormones like testosterone may increase the size of the prostate gland, especially in elderly men. Therefore your doctor will examine your prostate gland at regular intervals by digital rectal examination (DRE) and blood tests for prostate-specific antigen (PSA).
Additionally, at regular intervals, blood tests will be done to check the oxygen-carrying substance in your red blood cells (haemoglobin). In very rare cases the number of red blood cells will increase too much leading to complications.
The following blood checks should be carried out by your doctor before and during the treatment: testosterone blood level, full blood count.
Medical checks may also be necessary in some other conditions.
Talk to your doctor or pharmacist before you start using this medicine if you ever had, still have or are suspected to have:
Breast cancer which has spread to the bones;
Kidney or lung cancer;
High blood pressure;
Prostatic complaints, such as problems with passing urine;
Blood clotting problems – thrombophilia (an abnormality of blood coagulation that increases the risk of thrombosis – blood clots in blood vessels).
If you are suffering from severe heart, liver or kidney disease, treatment with Sustanon 250 may cause severe complications in the form of water retention in your body sometimes accompanied by (congestive) heart failure.
If you have sleep apnoea (temporarily stopping breathing during your sleep), it may get worse if you are using testosterone-containing products. Let your doctor know if you are worried about this. Extra supervision by your doctor may be necessary in case you are overweight or suffer from chronic lung disease.
During treatment you should also tell your doctor:
if you are a female-to-male transsexual. You should have special assessments, including psychiatric assessment, before treatment is started.
if you are a female-to-male transsexual and have a personal or family history of breast cancer and a personal history of endometrial cancer.
Children and adolescents
The safety and efficacy of this medicine has not been adequately determined in children and adolescents.
Extra supervision by your doctor is necessary in the treatment of children and adolescents since testosterone administration in general may cause early sexual development and limits growth (see section 4 “Children and adolescents”).
Blood tests may be affected.
For female-to-male transsexuals, Sustanon 250 may be given as part of a programme of treatment, including surgery.
Other medicines and Sustanon 250
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines – even those not prescribed.
Other medicines may influence the effects of Sustanon 250, or Sustanon 250 may affect other medicines. Therefore, you must tell your doctor or pharmacist if you are using, or are about to use:
Insulin and/or other medicines to control blood sugar levels;
Medicines to reduce the clotting of your blood (anti-coagulants);
Certain medicines that change the amount of enzymes to be made in the liver e.g. medicines used to treat epilepsy (phenobarbital).
These drugs may affect the levels of testosterone in your body and your doctor may need to adjust the dose or frequency of your Sustanon 250.
The use of androgens like Sustanon 250 may lead to a reduction of the doses of these medicines.
Tell your doctor or pharmacist if you are using or about to use the hormone ACTH or corticosteroids (used to treat various conditions such as rheumatism, arthritis, allergic conditions and asthma). The use of androgens like Sustanon 250 may increase the risk of water retention especially if your heart and liver are not working properly.
Androgens may also affect the results of some laboratory tests (e.g. thyroid gland). Therefore, you must tell your doctor or the laboratory staff performing the tests that you are using this medicine.
Sustanon 250 with food and drink
This medicine can be injected without taking consideration of meals and drinks.
Pregnancy, breast-feeding and fertility
Sustanon 250 must not be taken by women who are pregnant or think they are pregnant (see section 2 “Do not use Sustanon 250”), or by women who are breast-feeding.
In men, treatment with Sustanon 250 can lead to fertility disorders by repressing sperm formation.
In women, treatment with this medicine can lead to an irregular or absent menstrual cycle.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines
As far as is known this medicine has no influence on driving and using machines.
Sustanon 250 contains Arachis oil (peanut oil) and Benzyl alcohol
This medicine also contains:
Arachis oil (peanut oil) – If you are allergic to peanut or soya, do not use this medicinal product (see “Do not use Sustanon 250”).
Benzyl alcohol (100 mg per ml of solution) – Products containing benzyl alcohol must not be given to premature babies or neonates. Benzyl alcohol may cause toxic reactions and allergic reactions in infants and children up to 3 years old.
If you are a patient who participates in competitions governed by the World Anti-Doping Agency (WADA), then you should consult the WADA-code before using this medicine as Sustanon 250 can interfere with anti-doping testing.
The misuse of this medicine to enhance ability in sports carries serious health risks and is discouraged.
Drug abuse and dependence
This medicine should only be given by a doctor or nurse and used exactly as your doctor has told you. Abuse of testosterone, especially if you use too much of this medicine alone or with other anabolic androgenic steroids, can cause serious health problems to your heart and blood vessels (that can lead to death), mental health and/or the liver. Individuals who have abused testosterone may become dependent and experience withdrawal symptoms when the dosage changes significantly or is stopped immediately. You should not abuse this medicine alone or with other anabolic androgenic steroids because it carries serious health risks.
3. How Sustanon 250 is administered
This medicine should only be given by a doctor or a nurse. The injections are given deeply into a muscle (for instance in the buttock, upper leg or upper arm). The dose depends on your illness and how bad it is. Your doctor will decide the dose.
Usually, the dosage is one injection of 1 ml every three weeks.
If you have the impression that the effect of this medicine is too strong or too weak, talk to your doctor or nurse immediately.
Use in children and adolescents
The safety and efficacy of this medicine have not been adequately determined in children and adolescents. Pre-pubertal children using this medicine will be monitored by your doctor (see section 2 “Take special care with Sustanon 250”).
If you use more Sustanon 250 than you should
Your doctor or nurse will inject this medicine into you. If you have the impression that the effect of this medicine is too strong then please talk to your doctor or nurse immediately.
The following effects may happen:
Frequent erections in men;
Changes in your red blood cells (polycythaemia), which your doctor may monitor you for.
If you forgot to get your injection of Sustanon 250
Your doctor or nurse will inject this medicine into you. Should you miss a scheduled injection then please talk to your doctor or nurse as soon as possible. No double dose should be injected to make up for forgotten individual doses.
If you stop treatment with Sustanon 250
The effects of this medicine do not stop immediately after discontinuation, but gradually subside.
When treatment with this medicine is stopped, complaints such as those experienced before treatment may re-occur within a few weeks.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Adults (female-to-male transsexuals)
Doses vary from one injection of 1 ml every two weeks to one injection of 1 ml every four weeks.
4. Possible side effects
Like all medicines, this medicine can cause side effects although not everybody gets them. In general, the side effects which are reported with testosterone therapy include:
Common (may affect up to 1 in 10 people)
Increase in red blood cell count (the cells which carry the oxygen in your blood); haematocrit (percentage of red blood cells in blood) and haemoglobin (the component of red blood cells that carries oxygen), identified by periodic blood tests.
Not known (cannot be estimated from available data)
Changes in liver function tests;
Changes in cholesterol levels (changes in lipid metabolism);
Depression, nervousness, mood alterations;
Muscle pain (myalgia);
Fluid retention in the tissues, usually marked by swelling of ankles or feet;
High blood pressure (hypertension);
Changes in sexual desire;
Prolonged abnormal, painful erection of the penis;
Disturbed formation of sperm;
Prostatic growth to a size representative for the concerned age group;
Increased levels of a blood marker which is associated with prostate cancer (PSA increased);
Increased growth of a small prostate cancer which has not been detected yet (progression of a sub-clinical prostatic cancer).
Due to the nature of Sustanon 250, side effects cannot be quickly reversed by discontinuing medication. Injectables in general, may cause local reaction at the injection site.
5. How to store Sustanon 250
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date stated on the carton or label after the term “exp” (expiry date). The expiry date refers to the last day of that month.
Store below 30°C. Do not refrigerate or freeze.
Store in the original package in order to protect from light.
Do not throw away any medicines via wastewater or household waste. Ask your Pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.
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